Second Nephi 5:3

Yea, they did murmur against me, saying: Our younger brother thinks to rule over us; and we have had much trial because of him; wherefore, now let us slay him, that we may not be afflicted more because of his words. For behold, we will not have him to be our ruler; for it belongs unto us, who are the elder brethren, to rule over this people.

The only trials the older brothers had were of their own making. They had trials of their faith because they were faithless. They suffered in the wilderness because they would not obey. Their pride was hurt because they would not be humble. Nephi suffered far more at the hands of his brothers than they suffered because of Nephi. If anyone should be thinking of murder, it should be Nephi. The brothers have become so hardened in their self-justification and so consumed by their unbridled anger and envy, that they cannot simply turn their backs on their pesky brother and ignore him. Murder is the only option that will satisfy them. The same was true of the mobs in Joseph Smith's day. The Gentiles outnumbered the saints by orders of magnitude. They had all the power on their side. Yet they could not be satisfied until Joseph was dead. Persecution will rise again, fueled by the same anger and jealousy that Satan plants in the hearts of all those who align with him and fight against the truth.

Second Nephi 5:1

Behold, it came to pass that I, Nephi, did cry much unto the Lord my God, because of the anger of my brethren.

Our trials and afflictions are designed to cause us to cry to God. If that is our response, then our trials are truly blessings. Without the opposition of his brothers, Nephi would not have been the prophet he was. Because he turned to the Lord instead of to bitterness or revenge, he grew strong in the Spirit, and God could bless him greatly.  The stronger the opposition, the stronger we can become if we rely on God instead of our own strength. It is ironic that we can be the strongest when we feel the weakest.